Measurements of Thermal Damage in Biological Tissue Using Polarized Light Simulation
نویسنده
چکیده
Recently, thermal treatment has been used for collagen tightening and tissue contour enhancement. It is important to monitor the condition of collagenous tissue during and immediately after thermal treatment. When collagen is denatured, birefringence is reduced and a change in polarization state occurs. In this study, Monte Carlo simulation for polarized light was used to calculate the degree of linear polarization (DOLP) of backscattered light from thermally damaged porcine skins and the results were evaluated by comparison with the Mueller matrix. We observed a decrease in the DOLP and a rapid change in the colored regions of the Mueller matrix at temperatures ranging from 55 to 65°C. This could be attributed to the reduction of birefringence from thermal denaturation in the tissue. The DOLP method has a potential implementation in a real-time closed-loop feedback system with various thermal treatment methods by measuring the birefringence change in target tissue. KeywordsMonte Carlo simulation, polarized light, birefringence, collagen denaturation.
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